A new scientific discovery from the Clé de Peau Beauté laboratory reveals and visualises a skin gene network that is intelligent and has its own five senses
The skin may appear to be nothing more than a casing for your inner soul, or a surface to be shaved, sprayed, powdered, moisturised, lotioned, painted and otherwise controlled for reasons of beauty, comfort or vanity. However, it’s been clear for a long time now that the skin is not only the largest human organ but also one of the most vital in the body: its functions are far more complex and diverse than predicted decades ago.
As with our eyes, ears, nose and tongue, the skin is one of five sensory organs that channel information to our brain to help us perceive the world and make cognitive decisions like what coffee you’d like to have in the mornings or where to go for your next vacation. In an extended narrative, a theory now reveals that the skin is also an “intelligent” organ, separate from the brain.
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Above Inside the Shiseido Global
Innovation Center in
Yokohama, Tokyo
Skin Intelligence is the new discovery from Clé de Peau Beauté (CPB), the Shiseido Group’s global luxury skincare and make-up brand, that was revealed at a global event in Tokyo, Japan, this June. “When I visit a temple, my skin tingles and I experience a profound sense of awe. It is a sensation that is not easily explained, but one I recognise as Skin Intelligence,” says Dr Shinobu Nakanishi, research scientist at CPB laboratory.
According to CPB, Skin Intelligence is the skin’s innate ability to distinguish between positive and negative stimuli to maintain optimal condition at the epidermis level. Kiyoshi Sato, CPB’s chief technology officer, says, “When I first joined Shiseido (in 1993), our researchers had already been studying the intelligent potential of our skin. Our team strongly believes that the skin is more than just a membrane that separates the outside world from the inside.

Above Scent testing with Clé de Peau Beauté
The skin is smart
If the brain is intelligent because it is supported by the five senses to process, store and use information to perceive and solve problems, then CPB says that this is what the skin does as well, autonomously. Nakanishi explains the birth of this theory, “To begin, there are many microorganisms and single-celled organisms in the world. These single-celled organisms don’t have a brain. However, all living things have skin, and through skin, they can feel many things. That’s why even though single-celled organisms don’t have a brain, they possess the ability to sense their environment and evolve. This is possible because they can feel things through their skin, thus thinking with their skin. I strongly believe that the same principle applies to human skin as well.”
See also: Dr Kiyoshi Sato of Clé de Peau Beauté: “Clearer, brighter skin needs a healthy microbiome”

Above Clé de Peau Beauté La Crème

Above Clé de Peau Beauté Protective Fortifying Emulsion
Sato adds that the discovery that skin cells have receptors related to the five senses led them to Skin Intelligence. “The eye is responsible for sight, the nose is responsible for smell, and the ear is related to sound,” he says. “However, it was revealed one after another that the sensors related to the five senses in the brain are also present in the skin.
“To illustrate, let’s consider the sense of sight as an example. Our skin has a sensor that can detect UV light, which is invisible to the naked eye. When skin is exposed to UV light, it immediately reacts and forms melanin. This serves as evidence that the skin can ‘see’, and it’s this ability of the skin to adapt to the environment that solidifies my belief that Skin Intelligence exists.”

Above Clé de Peau Beauté developed Skin Empowering Illuminator from a proprietary blend of ingredients

Above Clé de Peau Beauté’s makeup range
Self-care for the skin
By understanding how Skin Intelligence works, CPB scientists are committed to discovering new technologies to address any damage caused by internal and
external aggressors (or positive and negative stimuli) and restore the skin’s innate self-care ability, enabling it to repair and defend itself. This is the most important catalyst for achieving radiant, healthy skin. Sato says, “It’s a waste to leave this skin’s ability (skin intelligence) asleep.” What has followed is the development of the Skin Empowering Illuminator, CPB’s proprietary blend of ingredients formulated into its Key Radiance Care range that supports Skin Intelligence.
CPB is also known for its iconic La Crème, or The Cream, which has more than 60 precisely selected components, each made to its best composition to address different skin conditions efficiently. Underpinned by Skin Intelligence, La Crème is effectively absorbed by the skin and promises to boost its capacity to renew and firm from within, where the skin gene 122 network comes into play.

Above Clé de Peau Beauté Firming Serum Supreme
Visualising the Skin Gene Network
“Similar to the brain, when the epidermal cells of the skin are stimulated from the outside, a network is activated within the skin. Although this network is not easy
to see as it doesn’t have visible lines like the brain’s, we have successfully identified it as the skin’s autonomic system. It appears that this network is closely related to skin intelligence,” says Nakanishi. “We have succeeded in visualising the communication between skin cells by employing mathematical science and molecular biology. I have coined this form of communication as ‘The Skin Gene Network.’”
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To bring the unseen autonomic system of Skin Intelligence to life and to inspire audiences around the world, CPB collaborated with renowned media artist Refik
Anadol. To commemorate CPB’s scientific achievement, Sato’s team provided the data cluster to Anadol, who then brought it to life with his artistry. Sato shared:
“Together we were able to reveal a world that we know exists and have been searching for a glimpse of for so long.”
The global event in Tokyo premiered Anadol’s immersive installation “Unseen Intelligence,” where the artist applies his trailblazing approach (he recently exhibited at New York’s Museum of Modern Art and presented at Frieze Week) to data narratives to envision the hidden world of skin. The collaboration between the beauty brand and artist is a parallel analogy between skin intelligence and artificial intelligence, from a perspective of “making the invisible visible”—or as Anadol shares, making the “unseen networks of our thinking organ, skin,” seen.
Credits
Images: Clé de Peau Beauté








