The show, to run from February 2 to July 14, promises to be "the largest and most comprehensive exhibition ever staged in the UK on the House of Dior," the V&A said in a statement.
"Spanning 1947 to the present day, 'Christian Dior: Designer of Dreams' will trace the history and impact of one of the 20th century's most influential couturiers," the statement said.
It said the expo would be "reimagined" for the V&A, the world's largest museum of decorative arts and design, displaying 500 objects, from accessories and illustrations to perfumes and a plethora of clothing, including 200 haute couture creations.
A highlight of the show will be the Dior dress worn by Princess Margaret for her 21st birthday celebrations, generously on loan from the Museum of London, the V&A said.