After graduating with a bachelor’s degree with honours in business administration from the then University of Singapore, Hsieh Fu Hua kicked off his career in merchant banking when he joined Morgan Grenfell Asia Holdings in 1974. He rose to the rank of managing director in 1985, and has amassed over four decades of experience in stockbroking, investment banking and fund management since.

Hsieh has served as CEO of Singapore Exchange, president of Temasek Holdings, chairman of Tiger Airways, and chairman of United Overseas Bank. He also sits on the boards of various non-profit organisations, chairing the National Gallery Singapore, the National University of Singapore, and the National University Health System. He was also president of the National Council of Social Service and chairman of Stewardship Asia Centre.

He is co-founder and adviser to investment advisory firm Prime Partners Group, which he co-founded in 1993; chairman of Asia Capital Reinsurance Group and a director of Grab Holdings. Hsieh is a member of the GIC Investment Board and the Human Resource and Organisation Committee. He was also appointed the chairman of the World Wide Fund for Nature Singapore (WWF-Singapore) in December 2022 and has been the chairman of National University of Singapore's board of trustees since 2016.

Outside the corporate world, Hsieh is active in charity. He was president of the National Council of Social Service from 2012 to 2018, and also founded his own private charity, BinjaiTree, in 2008. As CEO of Singapore Exchange, Hsieh kicked off The Bull Charge charity run to raise funds for the needy.