How will the royal family respond?
Buckingham Palace did not comment directly on the explosive pre-broadcast excerpts released before Sunday's interview. Weekend reports said they were unlikely to do so afterwards, unless individual members of the royal family were criticised.
Yet they still face tough questions about Meghan's claims she had suicidal thoughts and felt isolated while pregnant, and failed to get any support.
Racism accusations against an unnamed royal are particularly sensitive, with Meghan having been the first senior member to be of mixed race.
Black Lives Matter protests last year sparked calls for an urgent revision of the legacy of the British Empire.
Harry's older brother, William, and his wife Kate, will be watched closely for any response, given their involvement in advocating for better mental health.
See also: Oprah's Royal Interview: 10 Revelations From Meghan Markle & Harry